Read e-book online A Volume in the THE HISTORY OF NEUROSCIENCE IN AUTOBIOGRAPHY PDF

By Larry R. Squire (Eds.)

ISBN-10: 0080534066

ISBN-13: 9780080534060

ISBN-10: 0126603057

ISBN-13: 9780126603057

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Initially released in 1904. This quantity from the Cornell college Library's print collections used to be scanned on an APT BookScan and switched over to JPG 2000 layout via Kirtas applied sciences. All titles scanned conceal to hide and pages could comprise marks notations and different marginalia found in the unique quantity.

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AMA Arc/i Neurol Psychiat 1958;79:575-579. Aprison MH, Hingtgen JN. Neurochemical correlates of behavior. In Int Rev Neurobiol 1970;13:325-341. Aprison MH, Hingtgen JN. Hypersensitive serotonin receptors: A new hypothesis for one subgroup of unipolar depression derived from an animal model. In Haber B, Gabay S, Issidorides MR, Alivisatos SG, eds. Serotonin: Current aspects of neurochemistry and function. New York: Plenum, 1981; 627-656. Aprison MH, Hingtgen JN. Postsynaptic serotonergic action of antidepressive drugs.

Data reported by Vandenberg et al (1992a) also suggest t h a t threonine (THR 204) is important, and we placed this amino acid (Fig. 1,1) to hydrogen bond at region D between one of the nitrogen (N #4) hydrogen atoms located at the positive end of glycine and the hydroxyl oxygen atom of THR 204. We believed t h a t these hydrogen bonds and the pseudo-ring formation's ability to form a charge-transfer complex stabilize the glycine molecule at the neurotransmitter recognition site. Furthermore, when in this position, we believe the negative chloride ion, which is known to be hydrated, can bind to one of the two hydrogens attached to each N in the guanidinium group of ARG 271 and in the process lose some of its hydrating water molecules (Fig.

The consequence of prolonged reduced release of 5-HT should result in the formation of a hypersensitive receptor in the postsynaptic membrane of the serotonergic synapse. During the developmental stages of the disease and prior to the onset of depression, the decrease in the level of released 5-HT is probably compensated for by an increase in sensitivity of the receptor (hypersensitivity). This can occur when the number of 5-HT receptors increases or when the receptor becomes hypersensitive. An individual with this malady probably does not show all of the usual signs of depression; the hypersensitive receptors would handle the information as though a normal amount of 5-HT had been released.

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A Volume in the THE HISTORY OF NEUROSCIENCE IN AUTOBIOGRAPHY Series by Larry R. Squire (Eds.)


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