New PDF release: Advances in Immunology, Vol. 64

By Frank J. Dixon

ISBN-10: 012022464X

ISBN-13: 9780120224647

Study Institute of Scripps sanatorium, los angeles Jolla. learn within the box. For investigators. 19 individuals, 6 U.S.

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Additional info for Advances in Immunology, Vol. 64

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MHC-dependent antigen processing and peptide presentation: Providing ligands for lymphocyte activation. Cell 76, 287-299. Germain, R. , and Margulies, D. H. The biochemistry and cell biology of antigen processing and presentation. Annu. Rev. Biochem. 11, 403-450. Goldberg, A. , and Rock, K. L. Proteolysis, proteasomes and antigen presentation. Nature 357, 375-379. Grant, E. , Michlaek, M. , Goldberg, A. , and Rock, K. L. (1995). Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation.

Even if proteasomes work in this capacity, it is still unknown how they are able to recognize sizes and sequences in the given polypeptide antigens to generate the exact epitope peptides. These mechanisms need to be clarified at the molecular level. It is also important to accurately determine if immunoproteasomes indeed contribute to the accelerated antigen processing in response to y I F N stimulation, as was depicted in Fig. 5. Can they indeed be responsible for the production of cryptic epitopes?

Suh, W. , Cohen-Doyle, M. , Peterson, P. , and Williams, D. B. (1994). Interaction of MHC class I molecules with the transporter associated with antigen processing. Science 264, 1322- 1326. , Mott, R. , and Baumeister, W. (1995). The first characterization of a eubacterial proteasome: The 20s complex of Rhodococcus sp. strain NI86/21. Curr. Biol. 5 , 766-774. , Ahn, J. , Chung, C. , DeMartino, C. , Slaughter, C. , and Tanaka, K. (1997). Molecular properties of the proteasome activator PA28 family proteins and yinterferon regulation.

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Advances in Immunology, Vol. 64 by Frank J. Dixon


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